Olov Sterner Selected Research

galiellalactone

3/2016	The STAT3 Inhibitor Galiellalactone Effectively Reduces Tumor Growth and Metastatic Spread in an Orthotopic Xenograft Mouse Model of Prostate Cancer.
1/2016	Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells.
6/2014	Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells.
1/2011	Galiellalactone inhibits stem cell-like ALDH-positive prostate cancer cells.
2/2008	Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3.

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Olov Sterner Research Topics

Disease

8	Neoplasms (Cancer) 01/2017 - 01/2003
7	Prostatic Neoplasms (Prostate Cancer) 03/2016 - 02/2008
3	Breast Neoplasms (Breast Cancer) 01/2022 - 01/2014
2	Leishmaniasis 06/2021 - 04/2009
2	Inflammation (Inflammations) 01/2015 - 08/2005
2	Pain (Aches) 11/2011 - 08/2005
1	Chagas Disease (American Trypanosomiasis) 06/2021
1	Necrosis 01/2017
1	Hypercholesterolemia 11/2014
1	Dyslipidemias (Dyslipidemia) 11/2014
1	Insulin Resistance 01/2013
1	Type 2 Diabetes Mellitus (MODY) 01/2013
1	Hypoglycemia (Reactive Hypoglycemia) 01/2013
1	Seasonal Allergic Rhinitis (Hay Fever) 03/2012
1	Allergic Rhinitis 03/2012
1	Infections 10/2011
1	Mental Disorders (Mental Disorder) 10/2011
1	Chronic Obstructive Pulmonary Disease (COPD) 01/2008
1	Asthma (Bronchial Asthma) 01/2008
1	Airway Obstruction (Choking) 01/2008
1	Wounds and Injuries (Trauma) 05/2005
1	Edema (Dropsy) 09/2004
1	Colonic Neoplasms (Colon Cancer) 07/2003
1	Acute Promyelocytic Leukemia 07/2002

Drug/Important Bio-Agent (IBA)

5	galiellalactoneIBA 03/2016 - 02/2008
4	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 03/2016 - 02/2008
3	SesquiterpenesIBA 01/2017 - 09/2013
3	Pharmaceutical PreparationsIBA 09/2014 - 01/2008
2	LactonesIBA 01/2017 - 09/2013
2	damsinIBA 01/2017 - 09/2013
2	coronopilinIBA 01/2017 - 09/2013
2	DNA (Deoxyribonucleic Acid)IBA 01/2015 - 09/2013
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2013 - 09/2004
1	Biological ProductsIBA 01/2022
1	pulchrolIBA 06/2021
1	benzonidazole (benznidazole)IBA 06/2021
1	miltefosine (Impavido)IBA 06/2021
1	Cyclin-Dependent Kinase 2IBA 01/2017
1	ProdrugsIBA 01/2016
1	GPA512IBA 01/2016
1	oxidized low density lipoproteinIBA 11/2014
1	Cytochromes c (Cytochrome c)IBA 11/2014
1	CholesterolIBA 11/2014
1	Androgen Receptors (Androgen Receptor)IBA 09/2014
1	ISA-2011BIBA 09/2014
1	Small Interfering RNA (siRNA)IBA 09/2014
1	AntioxidantsIBA 01/2013
1	Blood Glucose (Blood Sugar)IBA 01/2013
1	C-Reactive ProteinIBA 01/2013
1	EnzymesIBA 01/2013
1	Streptozocin (Streptozotocin)FDA Link 01/2013
1	Capsaicin (Zostrix)FDA Link 03/2012
1	CalciumIBA 03/2012
1	AllergensIBA 03/2012
1	SB 705498IBA 03/2012
1	Acetaminophen (Paracetamol)FDA LinkGeneric 11/2011
1	N-Acetylneuraminic Acid (Sialic Acid)IBA 10/2011
1	gamma-Aminobutyric Acid (GABA)IBA 10/2011
1	Interleukin-6 (Interleukin 6)IBA 01/2011
1	Aldehyde DehydrogenaseIBA 01/2011
1	IntegrinsIBA 01/2011
1	2,5-dichloro-4-bromophenol (B 2)IBA 04/2009
1	Hormones (Hormone)IBA 02/2008
1	RESPIR 4-95IBA 01/2008
1	allyl isothiocyanateIBA 08/2005
1	allicinIBA 08/2005
1	Ion Channels (Ion Channel)IBA 08/2005
1	Narcotics (Narcotic Analgesics)IBA 05/2005
1	NF-kappa B (NF-kB)IBA 09/2004
1	hormonemateIBA 07/2003
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2003
1	verticillinsIBA 07/2002
1	Sch 52900IBA 07/2002

Therapy/Procedure

2	Castration 01/2016 - 06/2014
2	Therapeutics 09/2014 - 02/2008
1	Intraperitoneal Injections 03/2016
1	Intranasal Administration 03/2012
1	Traditional Medicine (Folk Remedies) 04/2009
1	Drug Therapy (Chemotherapy) 01/2003